Bisindole alkaloids from Voacanga grandifolia leaves
نویسندگان
چکیده
Two new bisindole alkaloids, 12?-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 2), were isolated from the leaves of Voacanga grandifolia, together with two known alkaloids. Their structures elucidated on basis 1D 2D NMR data. 1 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 very low cytotoxic a human cell line, HepG2 cells.
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ژورنال
عنوان ژورنال: Journal of Natural Medicines
سال: 2021
ISSN: ['1340-3443', '1861-0293']
DOI: https://doi.org/10.1007/s11418-020-01475-w